New York, 1926: Passionate and ambitious, young Antonia Brico dreams of becoming a conductor. Despite her talent and relentless determination, she faces many barriers as she tries to succeed in a very exclusive and male-dominated profession. The ultimate test for Antonia comes when the love of her life puts her in a difficult position, and she is forced to choose between love and music.

Spending his days as a rent collector, artist L.S. Lowry took art classes in the evening and painted well into the early hours of the morning. At the beginning of his career, as he yearns to transition into having his work appreciated in London and beyond, his disdainful mother is the ultimate obstacle to his success, not his lack of talent. However, Elizabeth is the very reason Lowry paints anything at all, as he desperately seeks to create something, anything, which will make her happy.